* Conference Event
% Exhibition/Scrimmage Event
Event times are (CDT)
| March |
| | 3 | 3:00 PM | Southwestern College | @ | Mid America Nazarene | 0-3 | |
| | | Game 2 | Southwestern College | @ | Mid America Nazarene | 3-6 | |
| | 5 | 10:00 AM | Southwestern College | vs. | Hastings College | 0-3 | |
| | @ Friends Tournament |
| | | 2:00 PM | Southwestern College | vs. | Hillsdale Free Will Baptist College | 14-1 | |
| | @ Friends Tournament |
| | 6 | 10:00 AM | Southwestern College | vs. | Doane College | 3-4 | |
| | @ Friends Tournament |
| | | 2:00 PM | Southwestern College | vs. | Central Christian College | 4-6 | |
| | @ Friends Tournament |
| | | 4:00 PM | Southwestern College | vs. | Benedictine College | 1-6 | |
| | @ Friends Tournament |
| | 12 | 9:30 AM | Southwestern College | vs. | Evangel University | 1-9 | |
| | David Fillmore Memorial Tournament-Springfield, MO |
| | | 11:15 AM | Southwestern College | vs. | Univ of Science and Arts of Oklahoma | 0-8 | |
| | David Fillmore Memorial Tournament-Springfield, MO |
| | 16 | 1:00 PM | Southwestern College | @ | Mid America Christian | 0-3 | |
| | | Game 2 | Southwestern College | @ | Mid America Christian | 5-7 | |
| * | 24 | 4:00 PM | Kansas Wesleyan Univ. | @ | Southwestern College | 3-4 | |
| | Final |
| * | | Game 2 | Kansas Wesleyan Univ. | @ | Southwestern College | 7-0 | |
| | Final |
| | 26 | 5:00 PM | Nebraska Wesleyan University | @ | Southwestern College | 5-4 | |
| | | Game 2 | Nebraska Wesleyan University | @ | Southwestern College | 5-4 | (9) |
| * | 30 | 4:00 PM | Southwestern College | @ | Bethany College | 2-6 | |
| * | | Game 2 | Southwestern College | @ | Bethany College | 6-4 | |
| April |
| * | 3 | 1:00 PM | Tabor College | @ | Southwestern College | 1-4 | |
| * | | Game 2 | Tabor College | @ | Southwestern College | 2-6 | |
| * | 9 | 3:00 PM | Southwestern College | @ | Univ. of Saint Mary | 2-4 | |
| * | | Game 2 | Southwestern College | @ | Univ. of Saint Mary | 14-6 | (6) |
| * | 10 | 1:00 PM | Southwestern College | @ | Ottawa Univ. | 1-5 | |
| | Senior Day |
| * | | Game 2 | Southwestern College | @ | Ottawa Univ. | 4-9 | |
| | 14 | 2:00 PM | Southwestern College | @ | Langston University | 11-6 | |
| | | Game 2 | Southwestern College | @ | Langston University | 13-1 | |
| | 15 | 2:00 PM | Hillsdale Free Will Baptist College | @ | Southwestern College | 0-9 | (6) |
| | | Game 2 | Hillsdale Free Will Baptist College | @ | Southwestern College | 2-8 | |
| * | 17 | 1:00 PM | McPherson College | @ | Southwestern College | 1-2 | (8) |
| * | | Game 2 | McPherson College | @ | Southwestern College | 1-4 | |
| | 19 | 2:00 PM | Southwestern College | @ | Hillsdale Free Will Baptist College | RAIN | |
| | | Game 2 | Southwestern College | @ | Hillsdale Free Will Baptist College | RAIN | |
| * | 21 | 5:00 PM | Southwestern College | @ | Sterling College | 0-4 | |
| * | | Game 2 | Southwestern College | @ | Sterling College | 11-7 | |
| * | 24 | 1:00 PM | Friends Univ. | @ | Southwestern College | 5-0 | |
| | Senior Day |
| * | | Game 2 | Friends Univ. | @ | Southwestern College | 4-2 | |
| | 29 | | Southwestern College | vs. | Ottawa Univ. | 1-8 | |
| | KCAC Conference Tournament |
| | | | Southwestern College | vs. | Sterling College | 4-1 | |
| | KCAC Conference Tournament |
| | | 12:00 PM | Southwestern College | vs. | Tabor College | 4-3 | (12) |
| | 2010 KCAC Softball Championships in Hillsboro, KS |
| | 30 | | Southwestern College | vs. | Friends Univ. | 1-2 | |
| | KCAC Conference Tournament |
* Conference Event
% Exhibition/Scrimmage Event
Event times are (CDT)
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